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The flap has a tremendous arc of rotation, capable of coveringlarge defects from the inferior chest down to the knee. As this process continues, the intercellular space becomes greatlydistended (arrows). The slope ofthe ?ow–volume pro?le during expiration is theexpiratory time constant (?exp), and the extrapola-tion of this slope to zero ?ow allows the estima-tion of the FRC. Jonesreports that she has never had a problem with her eyesor vision. Fully kerati-nized cells {blacklayer) are present in the center ofthe thymic corpuscle.X5,000. In this cohort ofnine patients, six were pediatric-aged rangingfrom 2 to 13 years old.

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